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The first-generation NNRTIs (efavirenz, delavirdine, and nevirapine) have a low genetic barrier to resistance and single mutations in the HIV-1 reverse transcriptase lead to class-wide resistance and virological failure.1 Generally, after treatment failure or development of toxicity, NNRTIs are replaced by ritonavir-boosted protease inhibitors

doi: 10.1152/physrev.1998.78.2.547

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